I've got a 204 in a Ruger #1 and it will take down coyotes and is a great chuck gun. I also have a Rem 700 chambered in 22-250 and if I had to choose I would go with the 22-250 for the simple fact that you will be able to reach out a little farther,with a heaver bullet and greater BC ( less wind drift) Only down fall is you won't be able to see your hits through the scope with out a muzzel brake.
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