I saw your post, and out of curiosity, looked up the PT-25. So, WITHOUT first hand experience (just looking it up on paper, so you should consider this information in this context), here are some observations:
The gun has a floating firing pin, no block. In my mind, that means you should carry it without a round in the chamber. ('m sure some will say otherwise, but I don't like a firing pin that is unsecured in a pistol that gets bumped around a lot...like in a purse). Since you said this was to be your wife's carry gun, that means she would have to pull it and rack it. That takes time in an emergency, and some people flub it anyway.
I don't know if you have kids or not, but having one of the newer guns with an integrated lock is a big plus...when the gun is not in your immediate posession (like a purse left in the kitchen...since this is your wifes gun) you can secure the weapon with a key. This is also useful if you leave the weapon in your car unattended, and a ton of other situations. You just have to remember that as soon as you pick up the gun, you unlock it, as soon as you put it down, you lock it. Since a gun should be checked anyway as it enters and leaves your immediate posession, this is no big deal.
.25 is a weak round. If this gun is truly emergency equipment, you would be better served with a higher caliber. On the low chance that it is actually used by your wife in an emergency, unless she is a crack shot in a crisis, there is a chance she could kill her assailant...but that he would die minutes later. Lots could happen in the intervening minutes between her shooting someone, and that person dropping dead.
For the most part, revolvers are a better choice for the majority of women who don't have a lot of "gun experience". They are simple to operate and comprehend and relatively inexpensive.
Snub nose "hammerless" or recessed hammer .38's tend to make a better choice...in my humble opinion. There are a variety out there from Rossi, S&W, Taurus, and others. Hammerless or recessed hammer models tend to be better for purses, as they are less prone to catch on something, and when training with the gun, the trigger pull is consistent for the end user...often at the range, people pull back the hammer while practicing for the lighter trigger pull, to get a better "score" on paper. This is not necessarily good training, considering the true purpose of a snub nose pistol.
