The S&W 13/65 is the perfect home defense gun. It has all the power to defend one's self against human intruders and, if you're out camping, it will do in a Sasquatch! It has the all the power of a Model 60 (one more round) and it's a much better balanced revolver. Sure, you can do the job with a Model 60, but unless you're going to carry it tucked away in your pajamas, why would you want to?
The .357 magnum is the best manstopping round in revolvers, and some would say it's the best manstopping round in handguns, period. Yes, that includes the big .44 magnum. When one uses a 125gr JHP, the round tends to stay in the body and creates a breathtaking (literally) blow to the miscreant. But in a home setting, you may find it excessive. Where the .357 shines is that it's incredibly versatile. You can use it in the home, while camping or on the road. It works on car tires, pops holes in vehicles and has excellent penetration and expansion. It also works on large animals, small game or people. (If Dennis Weaver had had a S&W 13 in the movie
Duel, the movie wouldn't have lasted 90 minutes...though it wouldn't have done much good in
Jeeper's Creepers!)
Some say the .357 Sig has as much stopping power as the .357 mag, but even if so, the auto won't take anything equivalent to the .38 Special loads. I'll take the 13, or a Ruger Security- or Speed-Six.