I love the stuff.
After about one hundred 45 Colt load experiments I still go back to Trail Boss as my most accurate powder.
I recommend these pet loads:
200 grain "Cowboy Action" Flat-Nosed Cast Lead Bullet with 6.7 grains of Trail Boss (Lee Dipper 1.6ml), 860 fps, for sub-1" groups at 25 yards.
225 grain Penn Bullets bevel-based Wadcutter with 6.0 grains of Trail Boss (Lee Dipper 1.3ml), 750 fps, for sub-1" groups at 25 yards.