I began handloading in 1978 and, while I had a few breaks with career moves, have been doing so for much of the last 34 years. I have never had an incident with any of my loads, though I did get a squib load with a box of factory Rem UMC .38spl when I was breaking in (though fortunately not breaking) a S&W 642.
I'm a low volume high quality-oriented loader. My typical work is, at most, 100-150 round lots for both rifle and pistol, using a turret press for handgun (as I like to use 4 dies to seat and crimp in separate steps and I load all my precision rifle rounds on a RCBS RockChucker. I also weigh each powder charge and, as long as I can keep variation to 0.1gr, I'm a happy camper. I find I get my best accuracy well below max loads, so I'm rarely worried about pressure issues.
FH