" no Grizzly"
Ok, moose, then, as they can be aggressive and are easily 1,500 pounds on the hoof. Usually encountered near water which restricts your movement.
Would you want to be armed with just a 10mm in a herd of 1,500 pound animals which require you to defend yourself? Compare that to say, .458 or .375 SOCOM with at least 2,000 foot pounds and 2,000 fps from the muzzle. My point is to show the slight, incremental difference of the 10mm cartridges is largely insignificant in the big picture. Trying to turn one or more galloping moose might need a lot more power and effort.
Of course, I say that having been out hunting whitetail with an AR pistol yesterday, the alternative choice was .45ACP. It was an easy choice, the 5.56 has 1,000 foot pounds of energy at 80m while the .45 doesn't rate that at the muzzle. Another example of what is or isn't a significant difference. Me, I would buy the less expensive 10mm ammo IF it's been shot enough to trust as a reliable in that pistol. As is, the minor ballistic advantage of one over the other is just one tick mark on a longer list of what to use.