With the herds I've managed, I don't shoot any doe I don't believe will dress at least 150. I've had a few "ground shrink," on over-estimation which dressed at 125-130, but I've also drug doe back to the truck which dressed 180-190lbs. So in doe, that's somewhere 165-250lbs on the hoof. For bucks, I don't usually target anything I think will dress under 180, so 225 on the hoof. The buck I took in 2011, my processor claimed would have gone 315-325 on the hoof, but I'd taken him with a rifle. He wasn't the biggest body in our herds that year, just had the most points out of the boys of the right age. My wife dropped an 8pt cull buck with a .357mag Redhawk shooting 158xtp's which dressed over 180lbs, which should be in the 240's on the hoof.
Presuming to predict your next comments, I will say, after working animals my entire life, and after participating in pugilistic and combative arts for over 20yrs, there is no man who has ever lived which would be pound for pound as tough as even a lowly whitetail deer. Whether a hog, dog, colt, calf, or sheep, I've not met an animal yet which yields as easily as a human. I'd carry a much, much larger firearm if I thought I had 250lb bucks might attack me, instead of 250lb men.