This reminds me of a Beretta Bobcat pistol dealer at a gunshow many years ago...
I was helping a friend look for a good home defense pistol (they settled on a Luger P08, what could I do). Anyways, as I was looking around, this guy at the table next to my friend waves at me, in that secretive way, and says "If you want something for good defense, come over here." I was curious, so I went over, and he has a very nice display of Beretta Bobcat Tip-up pistols. He holds one up, and tells me "Did you know you can take out a bear with one of these?" I honestly said I did not know that. He then goes into a long, excited explanation that if a bear attacked you in the woods, a shot up under the jaw of the bear would go bouncing around in the head of the bear and he would be dead. Now, in my mind, three scenarios were going on:
1. If the bear was that close, I would be out of ammo and throwing the empty gun at it while trying to run away.
2. By the time the bear is that close, chances are its going to be eating me while I try to get under the jaw line to shoot it.
3. If by some chance I am able to shoot the bear where the guy says I should, the bear is going to fall on top of me dead, and I would be joining him soon.
I thanked the guy, saying I would give it some serious thought before I left the gun show, and after my friend bought the Luger, I left. Now, the 22.LR. round is pretty awesome, but I wouldn't want to chance it against a charging, angry, hungry bear. 380 acp is a bit better, but still, better to get something like a 357 Magnum or the like. Your choice.