I got my first deer ever this year using some factory Hornady 450 bushmaster. It wasn't a big one, but I was still excited. I had passed on a few bigger ones earlier in the week because of high winds and not feeling confident that I could get a good, clean shot on them at 185 yards or so in the 20-25mph winds. Ended up with a small 65 or so pound doe from about 135 yards. From what I have eaten of it, it has been damn good so far. Bullet entered left side, smashed through one rib, annihilated the left lung, shredded the top half of the heart, ripped the right lung in two halves, punched through another rib on the right side, and made a decent size exit wound. Somehow, it still managed to run about 75 yards. I thought I must have jerked the shot and not gotten a very clean shot on it when I saw it dart off, but I sat for a couple minutes and then followed the blood trail and found it. While my neighbor was teaching me to field dress it properly, it blew my mind when I saw the carnage done to the vitals, but how far it still managed to run(especially after the same neighbor called me over to his house to help him field dress one he had just gotten so I could get a bit more practice and so he could be sure I had learned and correct any mistakes, and I saw how little the damage was on the one he took, but it dropped DRT). I had always heard they are "fragile" little creatures, but this one was apparently a tough little thing. Even the neighbor didn't believe me when I said how far it ran until I showed him where the blood trail started and where it ended.
Now I am looking forward to the December portion to try to fill the other two tags I got with my property. Again, I plan on going with the 450 unless I plan on taking a headshot with a 223, but I don't really feel good with my bullet selection for that(Hornady 55gr vmax which is a tack driver, 55gr fmj which is not an option, Hornady 55gr soft point that would probably be a perfect choice if it were more accurate, and then a few different grain sierra match kings that I don't use for anything other than punching paper or squirrels).
I plan on doing some load development in the next couple days to see if I can tighten up the groups any with the 450bm.