Personally I like my single actions to be chambered in a REVOLVER cartridge and honestly that goes for double actions for the most part, I don't mind a few DA's chambered in semi auto cartridges but to me the big frame Smiths and Rugers are too big for 10mm/.40. The GP100 10mm isn't bad, but it's a somewhat smaller revolver. To each his own but no, I definitely don't want a single action in 10mm.