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I used a Ruger 22/45 bull barrel for many years. I kept it loaded with 1 round of CCI Stinger for the occasional impromptu precision shot on a coyote or fox that was not in a trap. The mag was loaded with Aguila subsonic lead HP. I found these effective at dispatching up to coyote sized animals, and also effective on squirrel or rabbit at closer ranges. They generally did not cycle the action in colder weather, and had to be manually cycled. I found the large bolt handles on the Ruger to be easy to manipulate with heavy gloves and cold hands, and the firearm accurate enough for precision shooting. Also quieter than a wheelgun with the subsonics.