Given that you can clear a rifle bore at about 500 FPS with certain ease, I don't think that a light pistol load is going to be an issue in a rifle.
Where you could go afoul is taking a top-tier pressure rifle load and putting it in an old steel handgun.
Meh.
If you experiment with any old, old, olde olde olde 44 mag wheel guns- save the high pressure loads for something that'll take the pressure.
Beyond that..... I dunno, I've loaded max "rifle" loads in my 4" Taurus. I've also gone beyond that- don't do that at home kids.
Beyond "beast mode fireball" and "angry wrist" there was not a lot of worse for wear.
In a modern, sporting firearm in good condition
I would have no problem taking any of my 44 wheel gun loads and putting them in a rifle, or vice versa.
I would have a problem cheating the max rifle loads by about 15%, and putting that in a handgun again though.
That pressure spec over % is there as a safety margin- not the margin you should cut into regularly for entertainment.
It wasn't that accurate anyway- I don't really see the point.