Carrying a full size gun, year round, really isnt a problem, but you do have to want to do it. The real issue here isnt "cant", its "want".
Ive carried a full size pistol (1911 GM's/Commanders's, SIG P229's/226's, Glock 17's, etc), a double reload, and a BUG, most of my life, and never had any troubles doing so. I carry all day, every day, and I dont have a sedentary, environment controlled lifestyle. Its easily done, if you "want" to do it.
Ive always found IWB to be the best way to carry most things. Its very comfortable (once you get used to it), nothing shows below the belt, the grip is usually held in tight with a proper belt and holster, the pants help keep the gun in place, with very little extra movement. You wear your normal size pants, and a simple, light, loose over garment is all thats needed in the spring/summer (I normally just wear an untucked, unbuttoned Oxford type shirt). Sweatshirt or a fleece take care of the winter.
If youre active, and summers are warm, a kydex holster (full kydex, not one of the hybrids) is your, and your guns best friend. Its impervious to sweat, for the most part, and while you do get specific wear points on the gun, the rest of the gun is unmolested. Rust is pretty much eliminated.
Leather basically, and literally sucks. It sucks up sweat like a sponge, and then wont dry out until you take it off, and give it a number of days in a dry environment to dry out. Your gun suffers, and if your tee shirt rides up, or you dont wear one, you get to suffer to, as it will rub you raw, in short order (kydex just slides across wet/damp skin). Leather tends to wear a guns finish more quickly and more over all too, as it contacts more of the surface.
Where on your body are you planning on carrying the gun? Different places usually means different holsters. Some will do double duty, most wont. Best to settle on one spot, but you have to experiment to figure that out.
Blade Tech has a couple of reasonably priced holsters that will allow you to experiment. They also make good stuff, and even thought its priced reasonably, its good kit.