The first bottle neck I started reloading was the .270 win., and that was over 30 yrs. ago.
As far as powers and bullets also, I prefer the slow burning one's. Slow burner's are easier to obtain higher velocity and better accuracy with, land with significantly less pressure spike issues.
As for powders, I've had excellent results with RL22, RL19, IMR-7828, IMR-4350, H1000, and H4831 have all been very good performers. But as with any reloading endeavor / development, the rifle will often dictate which powders will perform best for you.
FYI, when reloading for bottle neck bolt guns, metering isn't really important, nor is it the best approach. Most who reload for bottle neck, and specifically when it applies to bolt guns and auto loading actions that shoot common big game cartridges like the .270 win., it's most beneficial, thus recommended that charges be individually weighed on a scale, not volumetrically thrown.
As for bullets, and regardless of what chambering, if it's for hunting big game, I've yet to use a bullet that performed better than the Speer Hot Core. They've been very effective and accurate in every chambering I've used them in. They're just a great bullet, and they don't cost an arm and a leg either. We killed 4 deer last week with them, all.270 win., and all were clean through and through heart lung shots, with the only exception being mine, in which I choose to shoot him in the neck, which was due to the extreme up hill angle he was at.
GS