1911 45acp
or
Glock 19
or
Ruger SP101 in 357 with 38spl ammo in it
+
a working cell phone
Hollowpoint ammo in the pistol.
I see no advantage to spending time retrieving multiple firearms, or even selecting which one to get. A pistol (for me) is convenient, easily accessible, and quick to ready. Pick one thing and go with it.
Those are proven pistol platforms that you (of course) must run to ensure reliability of your particular firearm, so you can trust them when it counts.
No matter what you have for home defense - baseball bat, golf club, pistol, shotgun, AR, AK, M60, you must have a PLAN and practice it. Just like fire drills at work and school, a drill at home ensures everyone knows what to do. Don't just rehearse in your head either (though there can be advantages to mental preparation like that), walk around your home and consider a scenario. Unload (if needed) and double check your defensive weapon, then go through the motions. Do it several times and consider how things will be.
In the moment is no time to think about the "easy" stuff. You will more than likely go into auto pilot and then when things get crazy/dynamic/super stressful, you'll be more prepared.
Example: I considered as part of my plan to walk back into a hall to check on my kid, then move forward to clear the upstairs. The problem? My kid keeps their door almost closed (not latched, just almost shut). I'd be walking backwards to keep facing the staircase in case someone came up, and I didn't want to turn to find and push the door open. Solution? I slowly backpedaled, focused on the top of the staircase/hallway and when I got to the door, I just did a hip bump to lightly but forcefully open it and then a quick side glance back confirms they're ok before proceeding forward again. No spur of the moment fumbling around to find and push the door open with my off hand.