As long as you have a barrel - meaning it's not some pepperbox where the muzzle is the end of the throat - slower powders will give faster velocities in any length barrel. The whole, "slower powders for longer barrels" thing is a myth. You do gain more in a longer barrel, but you gain no matter what. The only deviation to that rule is the burn rate which finally doesn't fit enough powder in the case to burn... I BADLY want H1000 to run fast in 6 creed to give me a little better barrel life, but compressing the hell out of it, I still look like I'm shooting a blackpowder musket, and I'm 200fps slower than H4350...
As a rule of thumb, if I find something in 223/5.56 I can't do with Varget, then I know I'm doing something wrong. Benchmark is my go-to in 6.8, and 8208 in Grendel.
I'll say firmly, I'll do a 6mm AR, Turbo, Fat Rat, or 243 LBC before I get suckered into a Nosler or Valkyrie. I've been throwing 80 & 90 grain 22 cal pills long distances for a long time, out of fast twist 22-250, 223AI, and 22-243's, and I've seen what I can do with a 6mm vs. a 22cal bullet first hand. Any time a guy pushes a 22cal fast enough to trump a 6mm, you start talking about triple digit barrel life, and while that works for some folks, I'd rather keep a barrel more than half a season.