Depends on which platform you prefer. Power wise the .45 Colt can be loaded to be very good for hunting pretty much anything. The 357 Mag is fine for social work and can even pull double duty as a deer gun. The reason I mention platform is that the GP100 has a much better trigger than the Redhawk does, plus it's smaller. The trigger system in the Redhawk is bad enough have turned me off to them, however the Super Redhawk has the same trigger system as the GP100 and you can get a 5" 454 Toklat or the smaller 2.5" Alaskan. You don't have to run 454, you could put .45 Colt in it, but always have the option for 454 if "needed", but there's not much a properly loaded .45 Colt can't do.