Many moons ago when I got into IHMSA handgun silhouette competition, I started competing with a 6" S&W Model 19, 357 Magnum. There was enough adjustment in the sights to reliably hit the 200 meter rams with the sights on the target.
Lots of magnum revolvers larger than 357 Magnum are capable of hitting out to 200 meters but in IHMSA, reliably knocking down the rams at 200 meters took a heavier bullet than normally used in a 357 Magnum. The high speed and flatter trajectory of the magnum round was part of the key.
I had to press my S&W Model 25-5 into service for one match. For the 200 meter ram, I had to aim about 20 feet above the berm to hit the 200 meter rams. If I hit the ram, it usually fell, but with the rainbow trajectory of the 45 Colt round, it was difficult to hit the target reliably.