So, as a person who's in the process of wading through local permitting, and a type 06 FFL, and has done massive amounts of research, and spent more than a couple of bucks on legal advice:
1. The ITARS requirement is gone for small arms ammunition.
2. There is no federal requirement for insurance.
3. Each state and locality has a different definition of what constitutes a home business, commercial enterprise, need for liability insurance, and any related permitting requirements.
4. Reloading ammunition and manufacturing ammunition are two different things. There is some grey here. Producing ammunition from all new components with the intent of selling it for profit is a clear and concise description of manufacturing ammunition. Reloading a previously expended cartridge provided by the other party (usually the brass case) for a reasonable charge for the cost of components used, and not done with the express intent of profit is NOT considered manufacturing by the ATF. This is where it would be up to you to dig into your local laws. So, TLDR; Reloading ammo with the intent of selling it for profit, especially if you use all new components, may constitute manufacturing. Reloading for you friends that bring you their brass, and reimburse you for the cost of the components is not manufacturing, but may not be legal in your state or local jurisdiction.