I only tried PRS22 using a bolt gun.
I found that if I practiced all stages at least twice before the match I did pretty well, concentrating on a building a good solid position for the non typical positions and barriers, and memorizing the rather contrived and complicated courses of fire I did pretty well. (they published all individual stages of every monthly match before hand on the PRS22 websight)
But... if I went to the match cold I found I could not memorize what order and distance the targets were to be shot at, and had no time to figure out a solid position given the different barriers and limitations given and did extraordinary poorly.
I also found a ranging reticle crucial, there is just not enough time to dial windage, elevation, and parallax turrets back and forth during the stage.
If you shot everything bipod prone, with no time constraints, and a written list of the target order, sizes, arc subtensions, and ranges with adequate wind flags I believe shooting 98% would not be unreasonable.
The difficulty comes in the typical stage senarios where you have to shoot weak side while standing on one leg with the rifle having to be no more than 12 inches off the ground, all while having to shoot 3 different sized targets at 3 different distances in the correct nonsensical order, all in 90 seconds that make it difficult.
It is kind of like playing Twister with a rifle while memorizing all forms of six different irregular Latin verb conjugations, with a time constraint that makes it impossible to complete the first time you try.
Coming from High Power I found that concentrating on building a stable shooting position given the different limitations and barriers given every stage very difficult and time consuming and got the biggest returns by figuring them out beforehand, compared to using the same 3 position and known distances every time in like in High Power.
I had ~$2k(+) wrapped up in my 22lr rifle/scope/bases/rings/bipod combo using $.35-40 per round ammo... That $2k wouldn't have even bought 1/2 of many competitor's scopes. Its not a cheap sport. I would think center fire would be even less so.