The scientists have just announced recreating the 1918 Spanish flu virus. It's a mutated avian flu. It kills fertilized bird embryos. Ordinary flu virii don't. The avian flu that is causing concern now also kills fertilized bird embryos.
That's not really the issue though...There has been a lot of bad information going around about what is an "avian" flu. So I'll try to sum this up as simply as possible.
Influenza (or flu) is always an "avian flu". Birds have every type of influenza known. Most don't kill the birds. They live infected with it just fine. And they spread it to each other and all of us by crapping everywhere. Everywhere there is bird crap there is probably some influenza. Even whales and seals get influenza from bird-crap. Humans, so far, have only been infected in large (epidemic/pandemic proportions) from 3 of the 16 different types of "avian flus".
The big hub-bub is that there is evidence that an additional bird virus will infect us. THAT is the worry and a good cause for alarm because it's a type of influenza that can cause very serious infection in birds, and based on a limited outbreak in 1997, a very serious infection in humans. Hence the hype, hub-bub, worry, terror, etc. It is also very different from the 1918 flu...
The different types of influenza are usually based on the sequence of two proteins that the virus makes: hemagglutinin and neuraminidase. You'll see references to H2N3 and H2N2 and H1N1. They are all the different versions of those two proteins. Without getting two much into what the proteins do, they are essential in the virus infecting us. The virus sets up shop in our lungs and starts destroying them. To beat the infection our body makes proteins called antibodies which block those viral proteins from functioning. However, the virus evolves to once again hide somewhat from the antibodies (whether you prefer by natural selection or intelligent design). That's why every year there is a flu season. Invariably some of us get stuck in bed, some feel like they're going to die, and many many people actually die a year from influenza and subsequent illness from a secondary infection. They are usually very young or very old and their bodies can't fight the influenza effectively before it causes serious damage to the lungs. Once you have serious lung damage, pneumonia typically will set in and cause death.
The spanish flu was of course an "avian flu" like every other flu. It was designated H1N1. It killed a lot more young adults-middle aged people than influenza normally does. For some reason it was more virulent. The Oct 7 issue of the journal Science has a research article about why it was virulent where researches remade the 1918 strain and infected mice to explore how it was different.
This new scary "avian flu" is designtated H5N1. Compared to other flus birds infected with H5N1 die in record numbers. There are two types of H5N1, "highly pathogenic" and "low pathogenic". The "highly pathogenic" strain has a mutation in its hemagglutinin protein (that's the H in H5N1) that creates a unique function that makes it especially lethal. Instead of the virus being stuck in a certain type of tissue (like the lung in humans), the highly pathogenic HA can be activated anywhere in the body. (The spanish flu does NOT have this mutation. It made mince-meat out of peoples' lungs but by most accounts was not systemic). This, among many other factors, contributes significantly to the virulence of H5N1.
The scare is that unlike the normal flu viruses humans are used to H1NX H2NX and H3NX which are respiratory diseases, H5 could theoretically be a systemic disease. Some isolates of H5N1 when introduced to mice (who have a similar response to influenza as humans do) cause systemic disease and high lethality. To be fair, some of the isolates only caused mild respiratory infections in mice. Therefore other factors besides the H5 with its systemic potential is responsible for actually causing virulent systemic disease.
However, if we do end up with a highly contageous human-to-human H5N1 that has the systemic potential factor and those miscelaneous factors required for virulence, it will make the spanish flu look about as bad as a head-cold. IF IF IF IF IF IF IF.
I do however have my tin-foil hat at the ready. If I'm dying I'll pretty much try anything just in case.
Oh and besides eating bird crap, the most common way people get even "airboune" influenza is picking their nose, rubbing their eyes etc, before washing their hands and not from aerosol particles. I'd recommend rather than stockpiling tamiflu (oseltamivir) which will probably do as much good as tic-tacs, is a hearty supply of 70% isopropanol or ethanol alcohol and squirt bottles. 70% ethanol/isopropyl alcohol is virucidal for influenza. That way you can liberally spray down everything you come in contact with and your hands frequently and massively lower your risk of influenza infection.
Just a tip.
References:
why the spanish flu H1N1 is so virulent:
http://www.sciencemag.org/cgi/content/full/310/5745/77
H5N1 replicates systemically:
http://jvi.asm.org/cgi/content/full/73/4/3184
general info about the bird flu:
http://www.cdc.gov/flu/avian/gen-info/facts.htm
Influenza is an "emerging disease" as there are so many that we have yet to get infected with. Makes you feel warm and fuzzy inside =)
http://www.cdc.gov/ncidod/eid/vol4no3/webster.htm
more can be found using google etc, but be wary of the source...