Well, in a Garand, you have to be careful about handloads and store bought ammo, the gas system is very sensitive and can be damaged by loads with heavy bullets or slow powders, more or less 30-06 and 308 would be very similar in most respects (recoil/ballistics), except for, 1. availability of parts, 2. availability of rifles, 3. availability and cost of ammo. This is outside of the whole "Patton would puke at the sight of a garand in anything other than -06"
CMP has good deals and support for 30-06 garands and ammo, and the few parts that are specific to each have much better availability in 06. Here lately because 308(7.62X51nato) is an actively used round, availability has been very scarce, or expensive OTOH 30-06 is retired, and mountains of it are available for cheap, both cost about the same to handload.
Another thing to note, the older garands have forged recievers, the new springers don't, and for the price of a new one, you can basically build a superior match grade original, refinish it and repark it.
For a little more versatility with handloads, an adjustable gas plug can help.
I bought mine factory refurbed from an old reciever in "super match" configuration for $1100 in nearly perfect condition about 8 months ago. I was originally looking for one of the new springers, but $1500 and 6 months backorder, for a rifle not as well suited for weekly target shooting and occasional competition seemed like a no brainer.