Being shot in the face with a .22 Short, from a Beretta 950Bs would have much the same effect.
Tghis page lists most of the available, at the time, 9x18 ammo.
In all of the tests, the heavy-weight loads averaged between 225-234 ft/lbs. As the available CorBon SD38090 gives you 220ft/lbs, that's not exactly a huge gain.
The Makarov is 6.34" in length, weighs 25.74 oz., and holds 8 rounds in the magazine.
The Kel-Tec P3AT is 5.2" in length, weighs 8.3 oz., and holds 6 rounds.
The Ruger LCP is 5.16" long, weighs 9.4 oz., and also holds six in the magazine.
The Kel-Tec PF-9 is 5.875" long, weighs 14.5 oz., and holds 7 rounds of
9x19 ammunition in the magazine.
The Kahr P-9 is 5.8" long, weighs 15.0 oz., and also holds 7 rounds of
9mm Pammo in the magazine.
My point was that the Makarov CAN be used for self-defense, but is marginal in size and power, according to many. SEVERAL other guns are available that are as cheap to buy, as powerful, and lighter and smaller. Several others are available that are definitely more powerful, but lighter and smaller, but more expensive.
It is, after all, your choice. However, there's nothing magical about the 9x18 cartridge, or the gun that it goes into. It was a different choice, made by a vastly different thought process, a long time ago.