sernv99, no, not a joke, signs were put up in various places by fed.gov warning US citizens to stay out of areas practially ceded to the cartels. Vekal Valley, about 40 miles from me, is known for bandits who prey on drug smugglers, and the cartels are rumored by law enforcement to have sent neforceres in to clean up the bandits. Go figure.
Does it affect day to day living? No. Could it? Possibly, depending on your activites and location, but I wouldn't reccomend hiking down on the border at night.
Tucson does have a very rich Hispanic culture mix, good resteraunts, and a bunch of great museums and sightseeing close to hand, including Colossal Cave, Karchner Caverns, Sabino Canyon, Saguaro National Monument, The Desert Museum, (MUST SEE!), Biosphere II, Tucson Rifle Club...well, it's not on most sightseeing lists, but for shooters it should be!
I don't know if the Gaslight Theatre is still in business - that place was a riot.