Just because my local dealer doesn't carry 25-06; didn't change my mind about buying two rifles in 25-06; which is my favorite caliber by far. That ammo problem is not even a problem. I ordered 10 boxes of 85 grain ballistic silvertips back in 2003; which is 200 rounds; I zeroed the scope; went on two predator hunts in Texas, am Awesome Coyote Hunt in New Mexico, plus countless coyote hunting here in the East; and I have 145 rounds left. They'll last me the rest of my life probably. All I did was order them from Natchez. It was easy, and I'm supplied for life. Now, if you must shoot at the range every year with that gun just to get some trigger time in; then maybe it's not for you; but once I zero a scope; that zero does not move; at least not yet. I get my trigger time in on a .223 at the range.
I just wanted to share that My choice is the 25-06; the 85 grain ballistic tip bullets are the ultimate Coyote Killer; BUT NOT IF YOU'RE COLLECTING HIDES. It flies out the muzzle at a blistering 3450 fps. Then, if you want to go on a whitetail or Mule Deer hunt; The 115 Grain Nosler Partition would be hard to beat(In this caliber). Although you can go to a 120 grain bullet if you want. However, I went with a 100 grain Nosler Partition for deer. But my 100 grain partition is loaded by Nosler Custom Trophy Grade Ammo and has a muzzle velocity of 3300; which is plain awesome for 100 grains. I was initially set on 115 grain partition; but with the velocity of this particular 100 grain load; I will have the ultimate long range deer round. Some people have their own set of rules; and will absolutely not shoot a deer with anything less than a 270; but you don't have to look hard to find many articles about how awesome the 115 grain partition is on terminal performance in a deer. I found many discussions of guys hunting deer with 100 grain bullets as well. If it was not intended for deer, Nosler Custom would not have chose the partition for their projectile. The partition style bullet has one of the longest track records of big game killing performance. Federal loaded the Triple Shock in the 100 grain load. These loads are just fine for North American Whitetails/Mulies. Please know that this is my opinion.
I do a lot of research but also have experience in the field, which gives me confidence that the 25-06 is a heck of a deer cartridge with 100 to 120 big-game bullets. And it is the ultimate coyote cartridge with 85 grain bullets. I just wanted to add to this discussion guys; I couldn't resist; because I feel so strongly about the 25-06; It's my absolute favorite. With very similar ballistics, the .243 is right up there with it. But I don't think you can go as heavy with the .243. However, you can go to 100 and I think I've read where people use 110 grain on .243; but I could be wrong.