"Anybody shot the 40 grain charge of 777 with a round ball over a chronograph? As big a fan of the round ball as I am, it is nowhere near what the 45 long Colt is, ballistically."
I dunno man, if someone were to shoot 40 grains of Triple Seven and a roundball (or a conical if you could fit it) at a bad guy he'd probably need to change his shorts. A remmy can be loaded pretty hot, close to .45 ACP, .44 Special, or even .45 Colt ballistics I suspect. Someday I will own a Chronograph and a steel framed New Model Army and I'll be able to test this for myself. But until then I still feel pretty safe having my Remmy by my bedside, I've seen what it can do.
If you'd use a .380, .22 LR or magnum, 9mm, .38 special, .32 ACP, .25 ACP for self defense you still are going to kill if you nail the bad guy in the heart or brain. Are they the most effective rounds? No. Can they kill a bad guy given you properly place your shot(s)? Yep. Plenty have been killed by a .22 short, and that's the smallest caliber you can get. I heard about some teen that got killed because his friend shot him with one of those Aguila pipsqueak rounds just to see what would happen, there probably was beer or pot involved I would imagine.
The gun I usually carry when I go to check the trot line isn't a big .44, it's my NAA Super Companion. I know it's only a .22 Magnum equivalent percussion revolver, but I know how to shoot with it and could easily defend myself with the little single action. The other bonus is it is really, really, loud with 2 grains of Bullseye. If I were to touch that gun off in the general direction of a bad guy he'd probably turn around and start running. But my Remington is louder and more powerful, indeed a better weapon.
My point is that if you have a gun, know how to shoot it accurately and effectively, and you are comfortable with it, and you choose it as a defensive weapon, then by all means use it if you need to. I am not saying there isn't better weapons than a blackpowder revolver, but if you know how to shoot effectively then you will have a very lethal self defense weapon. Of course it all comes down to the shooter and what he/she is capable of, heck maybe the bad guy has never fired a gun before in his life and just wants to rob, rape, or harm you.
I highly doubt that bad guys ever get out to the range to practice on human silhouettes. But if it were me, I'd choose my New Model Army. The boom would make them soil themselves or scare them away, the bullet has quite some force behind it, and the big bore and fat cylinder just looks nasty on the other end.
Just my two cents.
Levi