Locktite on Base screws?

I've never used it and never had a scope base or rings come loose. If I ever have a problem blue would be the correct choice.

FWIW, you can also use a drop of Tru-oil as a thread locker in a pinch.

The blue loc-tite also serves to lubricate the threads when installing, allowing for a much more accurate torque driver reading than a dry screw. Some manufacturers even suggest two different torque settings for lubed and dry screws.

I had a red dot sight come loose on my Ruger SRH . Blue lock tight solved the problem ! I cleaned the area of the rings , the mounting bolts with denatured alcohol prior o applying loctite ! Kevin

I never apply loctite, or any other thread locker to the screws on my scope bases or rings and so far have never had a problem on any of my deer rifles nor my heavier hitters like my 9.3x62, 338 Win Mag or 375 H&H. I think if you apply the right amount of torque, you should be fine.

I missed a pig because my base came loose; when I got into it to find out why I realized that, in a hurry, I had selected a cheap scope base made from aluminum w/ aluminum screws... Learn from my fail. First off, I had forgotten the loctite. Second, I believe the thermal differences between steel and aluminum allowed the aluminum screws to back out. I don't think aluminum bases are a problem, but steel screws are mandatory at my farm now.
I confirmed my zero after driving 14 hours, and that was enough heat/shock through the .308 to loosen it up. Late that night, I missed. Bummer, but I learned.

aluminum screws

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I've never seen any aluminum base screws before. I often use aluminum bases but they've always come with steel screws.

stripped

How fitting. My custom Swedish mauser started acting up a few weeks ago. I finally found the mounts loose. Tightened and lock tightewd 3 of 4. On number 4, the screw was stripped. Hoping it was just the screw, I tried another screw.... Stripped. Time to see a gunsmith to see if a number 8 screw will work, but there isn't much room on the action to work with. I am bummed.

Buzsaw, post #20 and you won't ever sweat it again.

I use the wifes clear nail polish have since early 70s, never came loose yet.

Purple locktite. It's very mild and I use it on lots of small screws that I don't want vibrating loose, while still allowing me to easily remove it later. Blue can sometimes be stubborn to remove. Red is for permanent applications.