Not fully proven, it seems
Hokkmike said:
For the distances normally applied to defensive semi-auto pistol shooting is there also a significant caliber restriction or difference with regard to effective range limitation?
There are two parts to your question;
1. How does accuracy change with distance? And,
2. How does incapacitation change with distance?
Accuracy is not particularly affected at all. Smaller calibers tend to have less overall range, so they tend to 'drop' faster. But not enough to affect accuracy.
"Effective range" is the distance where a projectile hit on target has a good probability of incapacitating the target. This, by the way is completely independent of any thoughts or theories about how far one 'should' be shooting to defend one's self.
One can also make the argument that no handgun has an "effective range"; that is, no handgun will reliably incapacitate an attacker. However, that's another argumentative position with little direct bearing on the question here.
Hokkmike said:
In other words, shooting across a 20 foot room for example, is there any notable difference in how you might aim a .380 as opposed to a .40? How far back would you have to be from a target to render the smaller calibers as unsuitable?
Within twenty feet, no. Yes, there will be a 'measurable' difference in impact sites - if the testing is rigorous and scientific. But not enough to make any material difference.
Hokkmike said:
I am wondering if the only real difference is that they would both strike their target OK but with varying results?
This is the real substance of the discussion. Within 'common' self-defense ranges - usually five to ten FEET - impact is not going to matter. However, all other factors being equal, a bullet with more momentum and/or kinetic energy will have more effect than a bullet with less energy.
No doubt you've heard the proverb, "A good hit with a small caliber beats a bad hit with a large caliber". It is true. However, a good hit with a large caliber beats a good hit with a small caliber.
One of the problems with self-defense shooting is the typical inability to make good, accurate hits on the attacker. My conclusion is one needs all the margin of error one can get. So one's defense sidearm should be as much as one can properly handle.