Glocks are no more reliable than any other modern , upper tier pistol. Maybe even less so with the way they setup their extractors, as @9mmepiphany mentioned.
I like the way HK does their barrels with the stepped chambers. It creates an issue with the cheap steel cased ammo but I only shoot...
I don't hunt with my 30-30, just need enough to put a hole in paper or ring some steel.
Reduced H4895 load-
25.0 grains with 110 grain RMR round nose
I also see Hodgdon lists Benchmark in their loads. That's a powder with a burn rate close to 4198, and may get you where you need to be.
My experience with Les Baer pistols is that they are built well with quality components, and they run.
I picked up my first Baer about 15 years ago. That choice was made because back then, Wilson was cutting corners on components by using MIM parts. I'm not going to get into the pros and cons...
That has been my experience but I don't load near max.
The only powder that gave me some grief when changing lots was 8208XBR. Primers started getting pretty flat so I turned the load down a few tenths.
I don't feel like the "more modern" cartridges have been released to replace the old ones. Typically, the new cartridge is introduced to fit in the short actions, or because of the need for a faster twist.
The 243 that I own is about a 10 year old rifle and has a 1:9.25 twist. It will not...
I had an R700 in 6mm Rem that shot the 65 and 75 Vmax pretty well- could slay prairie dogs at 300 yards, and currently have one in 243 that shoots the 65's into 3/4" groups. Pretty sure those all have 1:9.25 twists.
I have never tried reduced H4895 loads in 243 but have had really good success in several other cartridges.
H322 loads have worked for me in 308, and may work well in 243.
If the muzzle is threaded, a muzzle brake can work wonders.