All of the calibers mentioned are good. If you intend to hunt deer sized game I think the 6.5 Creedmoor or the .243 would be a good choice. Both are reliably accurate and ammunition can be found easily almost anywhere. Recoil is very manageable for both.
The 22-250 and .223 are also good...
The Red Lable is a good gun. Like any new production gun it had teething problems. Sad that they were not given more of a chance. If you look close at it it is designed similar to a Perazzi though not as robust. It has barrel trunions and locking lugs at midframe. It's profile is low to aid with...
7mm08 or 260 rem./ possibly a 270 if you want to hunt non dangerous game at reasonable distances. If you want to go 600 yds or so try a 280 AI.
Edit; to include a low mounted quality scope in 3-9x40 duplex or my favorite a straight 4 power with a #4 reticle
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