I belive that the Ruger Alaskan in .45lc/.454 is what we are going to get.
I love my GP-100 and have wanted one in .45acp for a long time. I'd guess that the Alaskan is as close as we'll get, in a Ruger production, my friend. But hey, same grip and trigger, so it's not all that bad.
JRLaws.