Good Point Craig.
If traveling into the wilderness of Alaska and I knew that I was going to need to defend myself against a brown bear I wouldn't choose a handgun for my 1st choice at all. Of my current firearms it would be my Mossberg 590 with a 20" barrel loaded with black magic slugs. (A guide gun Marlin/Ruger 45-70 would also be a good choice. New reason to buy a rifle.

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My backup handgun would be my Glock 20 loaded with hardcast. Yes, I still would pick the 10mm over my 44mag S&W 69 4.25".
I would open carry in a chest rig.
Neither the 44mag, nor the 10mm have a good success rates for 1 shot stops on big bears. Either cartridge is capable of penetranting the skull which would quickly end the fight!
Why the 10mm over the 44mag.
The 10mm has 3 times the capacity.
The 10mm is faster with follow up shots.
The 10mm is much quicker to reload.
The 10mm is much easier to shoot with one hand, even weak handed.
If you can shoot a 44mag quickly, you can shoot a 10mm quicker!
It may take 3 or more shots to anchor a bear. Give me more shots.
Sure I like the 44mag and I bought the 69 with the purpose of a wilderness carry. I have carried it as a walkabout gun in Wisconsin.
I would not be afraid to use my 44mag revolvers for black bear hunting. Loaded with a good expanding bullets! But defense is different than hunting!!