Please don't suggest a different caliber. Please answer the question as asked. Please explain your choice if you have the time. Please don't misunderstand my asking you to answer the question as asked as being nasty. Far too many time someone asks about one thing and is told to do another. LOL If you are going to shoot a .22LR round out of a 2.4" barrel handgun which .22LR round would be more effective as a man stopper? I really don't know if heavier is more effective in such a small bullet or an even smaller bullet traveling faster is more effective.