Just use the trailboss, then you will not need any filler or anything like that. I would not want to have any of it (filler) near my suppressor anyway. I bet you will have around 2/3 case fill, maybe even more. From what I have seen it is not position sensitive like many pistol powders.
I have had very good results with trailboss in 308. Large rifle match primer, No filler ever, fairly consistent velocity. Plenty good enough for 1.5 inches at 100. Targets at LR are no problem if you have a good MOA base and lots of adjustment on your glass.
Not sure about that bullet. Shorter stubbier bullets are easy to stabilize, but in 223 finding one like that might be tough. The flat nose 30 30 bullets have done well for me in 308, as have the round nosed ones. Again, not sure of any in 223 like that. Casting something could be done I bet if all else fails.
If that bullet does stabilize for you, go for it.
You may want to try loading it backwards. Sometimes that will get you better results since subsonic flight and supersonic flight prefer very different shapes. That is not to say the smk wont shoot well. My 300 blk shoots a 240 smk sub VERY well.
The heavier bullet should get you much better results than the typical 40 grain 22lr. Assuming you have a 1-7 twist by OP, I would think it would be fine. You should also note that the typical stability formula (ie the one we usually think of) is not optimized for subsonic projectiles.
I have always just done the "try and see" approach (WITHOUT THE CAN) anyway lol. Just remember to test stability at close range and further out. i like to shoot through a piece of cardboard into white regular paper. Helps to do it in different conditions as well.