I don't know how much unburnt powder you are seeing, but with all gunpowders there will be
some. A "clean" burning powder such as Titegroup does so with high pressures and high temperatures. The higher the pressure and the hotter the combustion the more complete with be the combustion. If however you are running the powder at an inappropriate low pressure level, you will have more unburnt powder grains come out of the tube, and the cylinder.
Keith was running his 429421 250 grain bullet with 17.5 grs 2400 in a 44 Special case. I have used that load in 44 Magnums with 44 Magnum cases. It is way too hot for most 44 Specials, and I am not too sure whether it is appropriate in N frames or Ruger Blackhawks.
Looking at the Feb 1953 American Rifleman Article on the 44 Spl, with cup data for the loads, a 250 Keith lead, 17.5 grs 2400 gave 1060 fps at 17,000 cup. The "hot" load I shoot is 7.5 grains Unique with a 250 Keith and that produced 12,500 cup. The standard pressure maximum load is a 240 with 6.5 grains Unique, no data given in the article.
I enjoyed reading Keith's stories but the hot loads he fired, in the vintage guns of the era, with the vintage poor steels, were extremely risky. I am surprised he did not blow more cylinders, maybe he did not fire all that many hot loads through any one pistol.