Last fall when I was working up my '06 loads for a new rifle for an elk hunt to Wyoming, I tried RL22, H4831, IMR4831, and IMR4350.
I ended up using the old tried and true load of 55.0gr of IMR4350 under either a Hornady 180gr SST, Nosler 180 BallisticTip, Hornady 180 Ptspt, and 180gr Remington CorLokt.
Of the bunch, the CorLokt was the most accurate at 100yds.Go figure! However, I carried the Ballistic Tips as I had the most of them.
From the 24"bbl of my Colt Light-Rifle, I was getting right at 2,800fps.
However, my Savage M110 LH, won't easily extract this load. It prefers for accuracy and ease of extraction, 54.0gr for around 2,700fps from it's 22" bbl. It has a much tighter chamber and shorter throat than the Colt, which still has a tight short chamber and throat.
With the Savage I took a 130lb doe in Alabama in December with a shoulder-spine shot. Performance of the 180gr Hornady Spt was splendid. I'd always used a 165gr or lighter bullet. From now on though, a 165gr is going to be the lightest I use in an '06 so I don't have to resight for a western elk hunt. I've decided I really like the 180's. (Yeah, I know! the 150's will work on elk- my brother has killed several with his .308 and 150gr Nosler Partitons....)
Sighted in 3" high at 100yds the 180's will give you a zero of about 250yds. All you need for most any N.American hunting.