In the two 22" .30-06's I've loaded for, warm accuracy loads were a bit over 2,900 fps for the same 165gr bullets, and right at 2,800 fps for 180gr bullets. All loads at or under book max with temp resistant powders (a personal requirement for hunting rifles). From my experience there's is 170 fps to 200 fps difference between the .308 and .30-06 with best loads, or about the same difference as between the .30-06 and the .300 WSM Does this difference matter? On deer, which is what the vast majority of hunters hunt, I'd say no, deer aren't hard to kill. On larger game like elk and moose? Most folks, myself included probably don't have enough actual experience shooting big game with both to give an informed opinion. I know one guy who has killed a bunch of elk over the years with a .308 Winchester 88, he now shoots a .300 WM, mostly just to try something different. He 's knocked over three big bulls with it in the last two hunting seasons and thinks that with good hits they go down a bit faster and require fewer follow up shots. His son, who also successfully hunted for years with a .308 bought a new .30-06 to hunt with a few years ago and likes it. This stuff is really not worth arguing over.