After loading for 40+ years, I've tried most out there. What I use today for 99% of my loading with .38/.357 is 4 powders. Bullseye for 148gr HBWC for my 25 yard getting serious target shooting. Universal with Hytek Coated 130gr and 158gr for the majority of my shooting which includes shooting plates up to 100 yards. H110 & 2400 for Hunting and also shooting some long range target. I use H110 with 180gr Hytek Coated for Hog Hunting and 2400 for 158gr Jacked HP for Deer Hunting. Would probably use 2400 for all of my hot magnums, but the H110 shoots the 180gr Bullet much more accurate at 50 yards and does give me a little more velocity but that is icing on the cake. 2400 would push it plenty fast enough and 2400 doesn't have to be pushed close to max to get a good load like H110. I would never say what I use is the best. Its just what works the best for me. There are a lot of good powders out there today and sometimes you just have to try different combinations to see what works best in your particular gun. That is what is so much fun to me about reloading. Sometimes the smallest adjustment can make huge differences in accuracy.