Howdy. First post, though I've lurked on this site and its archives since I was a teenager (2008) and became obsessed with firearms and ballistics. I've been doing a lot of research about the Judge and the Bond Arms 45LC/410 derringers lately, and I've come up with a question that I've not found an answer to anywhere. Everywhere I go, folks ask about 45 Long Colt vs 410 slugs, and the conclusion every single time is that a 45 Long Colt is vastly superior to any 410 slug. I can easily see why, as every commercially available 410 slug has a 9mm Luger-esque bullet weight of around 120 grains and pathetic velocity out of a handgun, while the 45LC pushes 250 grains to 900 fps and above. My question though is WHY??? Why is nearly every available commercial 410 slug pathetic? The cartridge is much larger than a .45LC, and SAAMI specs the chamber pressures about the same, so howcome almost no one makes high-powered 410 ammo? The way I see it, if I put 250 grains of buckshot (000 or 00 or whatever fits) into a 410 2-1/2 inch shell and propel it to 900 fps with handgun powder, that would generate chamber pressure very similar to a 45 Long Colt, and would therefore be plenty safe to shoot in a handgun designed to fire both cartridges. So what's the hang-up? Is this somehow unsafe? Is it not possible? Note: I am not asking this for personal defense reasons. I am well aware that there are far better options out there. My question is mostly academic. Also I want to be able to handload 410 and not feel like I'm wasting my time.