Getting back to this and first thanks all for the replies, much appreciated. Some general thoughts in response:
- "A 22 is better than nothing" (etc) only states the obvious, but that wasn't my question, which is probably my bad, I didn't state it well enough to begin with. The thing I'm really kicking around is if a 22 might be a better choice due to much lower recoil, since that can impact accuracy quite a lot and so should in turn (I think) equate to more hits in a crisis situation. Basically a hit with a 22 beats the hell out of a miss with a bigger caliber.
- I don't see that a 380 is a viable "in between" option as the recoil on that is much closer to a 9mm than a 22. If it was half-way between the two, it would be more of a consideration.
- I don't get the rifle suggestions-? It seems to me a rifle would be an impractical weapon in close quarters of a house. If I'm shooting kids to get off my lawn however

- Most break-ins are by people unarmed, and most aren't all doped up on crack/PCP/etc. So tbh I'm not too worried about the "crazed druggie." Someone however did make a good point about if they have heavier clothing on.
- "You have less of a chance of killing someone" is a plus, not a minus, in my book. I've no interest in killing someone, even a dirtball who's broken into my house. Only stopping them.
Really I'm not sold on 22 vs something else offhand, again just thinking out loud.
All of this makes me think there could be a viable market for a caliber that is truly half-way between a 22 and 380. A "30" perhaps. A true half-way between a 22 and 380.