I kind of feel like CraigC in the sense that if you may hunt whitetailed deer and perhaps black bear, any of the 270 > 30-06 calibers are fine, back it up a little in power or move up a little in power to the 7mm or 300 win mag; just fine. I do think the '06 is the do it all caliber if you just have to choose one contrary to Craig. The caliber range stated is plenty of viable choices until you start hunting dangerous game. As was mentioned the 30-06 is rated the #3 caliber in Alaska for dangerous game. I don't really want to be shooting 338's or 375's just because I might some day hunt Alaska. I'll buy it for the the trip. Unless you live there, if you can afford the Alaska hunt, you can afford the new rifle.