Wow guys, I really appreciate the overwhelming responses. I ended up getting her a Heritage Rough Rider in .22 LR at the gun show saturday. NIB, out the door for 145 cash money. I think it'll be perfect. Fits her hands just fine, and she can work the hammer with her off hand easy as pie. Works a lot better for her than my old Ruger Mk I. And for all the many people who were suggesting compact .380 and 9mm (or .357?!?!) guns for her, you must have missed the part where I mentioned she was an old lady with nerve damage and some weakness in her hands, and that I was looking for a .22 for range/plinking only, not defensive use (no, I'm not dumb enough to get her a single-action .22 with a 6+ inch barrel as her concealed carry piece). She's only shot guns once before, is still not very comfortable handling them, much less carrying one daily. I hope she gets to that point, but for now I just want to teach her the basics of shooting and safety. Again, thanks for all the suggestions!