Sheesh! Y'all think for a moment: "Vitals" means different things to different people, for one thing. Ease of hitting some critter in a clean-kill spot will vary with the situation. Some angles, a .223 is fine. Other angles, a large and heavy bullet is far superior. There is no "one size fits all".
"Marksmanship", also. Some of us get in a lot of trigger time. Many folks don't. Give other members credit for being trigger-time folks, not "one box a year" types. Just general principles, to save arguing.
Next: What's the most common use for some particular rifle/cartridge package? Mostly little stuff, or mostly hogs? If mostly hogs, go bigger than a .223--that general principles thing again. If only occasionally hogs, the answer for a .223 guy is to be pickier about what shot he's actually gonna take.
In posting, more thinking beats more hurrying. Avoid the syndrome of, "I gotta get this wondrous, definitive answer posted before somebody beats me to it!" that shows up all too often, okay?