I'm a 1911 shooter and have never had that experience. How aggressive is the grip checkering or your Springer's stock grips? If it was me, I think I'd experiement with different grips before I give up and shoot with gloves. You could go less aggressive wood, smooth wood, or rubber.
I also wonder if you might take a tigher hold. It seems to me that there are two factors involved in blistering: (a) an abrasive surface (b) moving around against soft skin. I'd eliminate one or both.
If you intend to use this pistol at all for self-defense, I think one should practice is the mode the gun will be used. If the SHTF, you're not going to say "hold it right there while I put on my gloves."