I just looked at the gun on their website. Here's how I see it. The "Southpaw" is a self-defense gun. In a gunfight, your mind is jacked with adrenaline. It comes time to reload and you're desperately looking for the cylinder release latch.
It's not a gun I would want in a "panic" situation. I've been panicked before, and you only do that which you're already conditioned to do.
In my case, I've been conditioned to shooting S&W, Colt and Ruger revolvers.
Even my Dan Wesson was kind of hard to get used to. That's why I sold it.