My preference?
When you need a gun, you need it now. When I'm target practicing, I don't care if it has a safety. I can remember to take it off, and if I forget, the gun simply doesn't go bang. When I'm hunting, I'm often walking, so having a safety is a good idea, in case I trip and my finger or a stick ends up in the trigger guard and presses the trigger.
However, if I need a defense gun, I need it right now. I need to be able to make it to go bang before the other guy can make his go bang, or if he's already shooting, before he can land one in me.
And I don't want anything to slow up that process that can get me killed. So for me, I refuse to carry something that requires a safety to be carried safely. No 1911s, etc. I have a Ruger P90 .45 ACP that I've used in IDPA, and several times after loading and making ready I've forgotten to flick the safety off after dropping the hammer. When the timer goes beep it's only embarrassing when the trigger doesn't do anything. However, when you're life is on the line, the bg doesn't give you a second chance. And the consequence of forgetting to take the safety off is way beyond a little embarrassment.
So it's revolvers or DAO or DA/SA with a dedicated decocker, but no combo decocker/safety.
My preference and my reasons. Yours may vary.