Also a majority of hunters, hunt with some form of long gun, Handgun hunters are a minority. My deer gun a revolver. Over time have used 357 mag, 41 mag, 44 mag, 45 Colt and 454; Among these, my preference is 41 mag, but have used 45 Colt for a longer timeframe. Some years ago, a lot of gun writer ink was spilled about the effectiveness of a 250 gr 43 cal bullet at 1200 fps. This load, in my experience, is about the max that is truly Comfortable to shoot. 250 gr at 1200 fps is an easy load in 41 mag, that is why I favor The 41. A dozen or so years ago, when I acquired a FA83 in 41 mag, the dealer asked Why I wanted 41. He was shooting a FA in 454, but admitted he could only go a couple Cylinders. Before I could get my answer out, another guy talked about how enjoyable The 41 is, especially compared go 454. For me, 41 mag, is the right balance of power and shootability. Other cartridges are nice choices, I think if a handgun hunter is Really honest with her/himself, they too will find the 41 mag to be optimal. PS, slightly off topic - another highly effective and shootable deer load Is 255 gr SWC in 45 Colt at 950 fps.