If I had a caribou to hunt I would probably use it too. I think it is a great cartridge. Groundhogs and coyotes is all I have used it on, so far. I had an opportunity to moose hunt in Ontario with the folks that ran a fishing camp on a remote lake. I was talking with the old resident trapper who was going to be our guide. I told him all I had for a rifle was a .243. That's when he said, 'you dont shoot a moose with a varmint gun". So before I headed back up to Canada for the hunt, I bought the cheapest .30-06 that I could find. an H&R handi in .30-06. So that's what I did under the very same circumstances.