I leave my CCW loaded in a quick access safe, and the CCW safe is a shorter reach when lying in bed than the quick access safe I use for my home defense pistol, so I'd likely go for that first (when the HD gun is locked up), and until I go to bed it is still on me so then it is what I go for first as well. So, usually a P365 (9mm), Taurus 856, Taurus 85CH, S&W 442, Colt King Cobra (3" new model), Glock 19 or CZ PCR, and until this week when I retired it from the rotation, a 1st gen S&W M&P40c was also on that list. My home defense pistol is not always left in the quick access safe. I often use a 1911 type pistol, with the extra step of the safety, I feel comfortable leaving it in my nightstand or under my pillow when I don't have anyone visiting. My choice is my Commander sized S&W 1911SC (1st gen), it is my only 1911 that has been 100% through many thousands of rounds. I also like revolvers for HD, so I'll sometimes load up my S&W 65LS with .38spl (no magnums indoors) or my .45LC S&W 625MG.