I think hold over out to 400 yards can be estimated well enough from the body size of a deer or elk, probably 14 to 20 inches if zeroed at 200 depending on your cartridge and load at least for anything I'm likely to use. Maybe 6 inched or just aim a tad high at 300 yards. But, at 500 or 600 do you use an adjustable turret or just practice until you can estimate the hold over ? If you use a turret, how does that work out in hunting situations ? How fast and how much trouble is it to get done in a changing situation ? Or, do you use some of the scopes with several horizontal cross hairs, and how does that work? Is it set up for a common velocity and bullet drop or can you get it altered for a specific bullet drop? Do you use a rangefinder?